LC-MS Grade Solvents and Reagents
LC-MS: Raising the Bar on Purity
Liquid chromatography – mass spectrometry (LC-MS) is fast becoming a routine fixture in today’s well-equipped analytical laboratory. Along with the increased use of LC-MS comes instrumental, chemical and database methods aimed at increasing the sensitivity, specificity and speed of analysis of this invaluable technique. New ion sources, high-resolution LC systems and rapid mass spectrometers with enhanced ion optics and detectors have lowered the limits of detection, but have raised the bar on the purity expectations of reagents used for sample preparation, mobile phases, and as additives. Some notable examples of how the purity and composition of the chemicals used in LC MS that affect the analysis include:
- Polymers—including biopolymers such as proteins and DNA—form adducts with inorganic salts, leading to complex mass spectra and a broad distribution of multiply charged sodium, potassium and chloride adducts
- Salts can suppress ionization in ESI sources, even with small molecules
- Reagents, solvents, and devices used in sample preparation along with additives always present a risk of contamination
For an overview on our HPLC/UHPLC column offer, please visit SigmaAldrich/HPLC.
Solvents and Blends for LC-MS | Superior Resolution and Sensitivity
Why Use LC-MS Grade Solvents?
- No ghost peaks
- Full reproducibility
- Extends the lifetime of your columns
- Optimized and tested for LC-MS applications
- Minimal background ion suppression
- Global availability
Why Pre-Blended?
- Reduces the risk of contamination
- Saves time
- No cleaning of glassware or filtration
- Less exposure to hazardous chemicals
As LC-MS is a highly sensitive analytical technique, impurities in your solvents can have an impact on the accuracy and reproducibility of your analytical results. Have confidence in your analysis by using our high purity solvents and blends designed to meet the demanding requirements of LC-MS applications, ensuring baseline stability, lowest impurity levels and, in addition, high UV transmittance.
Developed specifically for LC-MS, we have introduced a range of high purity solvents pre-blended with acetic acid, formic acid or trifluoroacetic acid, to provide convenient ready-to-use mobile phases for accurate LC-MS.
This complete product portfolio sets the standard for accurate, reproducible and high-resolution analytical separations for superior performance and sensitivity.
For more information visit SigmaAldrich.com/lcms-solvents.
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