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Improving RNA research results with LNA technology
How does locked nucleic acid (LNA) technology affect RNA results?
LNA (locked nucleic acid) oligos bind with much higher affinity and specificity to RNA targets than standard DNA and RNA oligos. This enables specific and sensitive detection of small RNAs and discrimination between highly similar sequences. This webinar will present the unique features and benefits of LNA and discuss how your microRNA qPCR experiments and your functional analyses of RNA will profit.
LNA substitutions increase oligo melting temperature, enabling Tm adjustment and normalization. This makes LNA optimal for designing short, high-affinity PCR primers and antisense oligonucleotides. LNA also allows detection of rare RNAs, even when limited to less sample material or complex samples with low RNA content. As LNA also increases the Tm difference between perfectly matched and mismatched targets, even closely related sequences can be accurately discriminated in qPCR profiling and silencing.
Due to their short length, high-affinity LNA antisense oligonucleotides are taken up naturally by cells. Highly potent once inside cells and resistant to enzymatic degradation, LNA antisense oligos effectively silence RNA in a broad range of animal tissues – making them the tool of choice for revealing RNA functions and evaluating their therapeutic potential.
QIAGEN has merged our cutting edge technologies with Exiqon’s twenty years of experience in LNA oligo design to enhance qPCR technology, in situ hybridization, functional analysis of RNA in cells and animals, miRNA and RNA sequencing and much more! Join this webinar and learn how to take your RNA research to the next level!
• Live Webinar: Take your RNA research to the next level with LNA technology
• Speaker: Roman Kurek, Ph.D., Senior Customer Solutions Manager, Genomics, QIAGEN
• Date and Time: October 31, 2018 at 9:00 am EDT and 2:00 pm CET