August 15, 2019 at 8am PDT / 11am EDT / 4pm BST / 5pm CEST

Alongside intense efforts to exploit T-cells as immunotherapies for cancer (e.g. checkpoint inhibitors, CAR-T, T-cell metabolism), researchers are increasingly considering other immune cell types for novel targets. One example is the enhancement of macrophage function via inhibitors of CD47 “don’t-eat-me” signaling proteins, enabling tumor cells to evade clearance by neighbouring phagocytes (Kim et al, 2012, Leukemia 26, 2538–2545). In order to identify new CD47 and phagocyte modulators, novel, direct and validated assays with throughput commensurate to drug discovery are required. Watch this webinar to learn how:

• Real-time live-cell analysis using pH-sensitive fluorescent probe-labeled target cells can be used to visualize and quantify phagocytosis.
• You can share data on the pro-phagocytic effects of anti-CD47 antibodies.
• Other live-cell phenotypic assays (e.g. apoptosis, proliferation) are used to validate mechanisms of action.

Certificate of attendance All webinar participants can download a certificate of attendance, with a learning outcomes summary document for continuing education purposes.

Dr. Tim Dale
Head of BioAnalytics Applications Sartorius Corporation Sartorius

Tim co-founded the European laboratories of Essen BioScience in 2009 and is Head of BioAnalytics Applications, Sartorius Corporation, managing R&D operations.  A highly experienced industrial pharmacologist and leader with more than 20 years of service, Tim has a track record in applied drug discovery.  Applying his knowledge and expertise to drug discovery programs in the neurology, psychiatry and gastrointestinal therapeutic areas, he has contributed to the progression of a number of candidate molecules into clinical studies.  Tim has co-authored over 20 publications and patents relating to pharmacology, ion channels and cell-based assays.  Most recently, Tim is applying his many years of experience to extend the portfolio of cell-based applications utilising live-cell analysis in the fields of oncology, immunology and neuroscience.

Dr Lois Manton-O’Byrne
Editor SelectScience

Dr Lois Manton-O’Byrne is the Editor of SelectScience. Lois plays an integral role in shaping the content of the SelectScience communities, particularly chemistry and applied science, and engaging with scientists. She studied chemistry at the University of St Andrews, and later achieved a PhD from the University of Bath, focusing on sustainable plastics.

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